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Major hospitals and specialized clinics are concentrated in large metropolitan areas

doi: 10.1073/pnas.2306776121 13 DebrasCChazelasESrourBKesse-GuyotEJuliaCZelekLet al

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A clinically responsible plan still depends on: Protein intake and resistance training to protect lean mass during weight loss Sleep quality and stress load, both of which shape appetite and metabolism Insulin sensitivity, thyroid markers, and a review of other medications where relevant Realistic, monitored expectations rather than rapid-loss promises If the fundamentals are ignored, even the most powerful peptide underperforms, and rebound weight gain is common once it is stopped